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Insights from an international team include identification of beneficial bacteria that thwart disease

Ovarian cancer discovery could turn failed treatment into lifesaver

University of Virginia Cancer Center researchers have explained the failure of immune checkpoint therapy for ovarian cancer by discovering how gut bacteria interfere with the treatment. Doctors may be able…

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PPP
Tumors can drive thrombosis by releasing chemokines, secreted proteins that can circulate to the lung. This image of a lung sample shows how immune cells called macrophages release small vesicles (green) that attach to platelets (magenta), which can form life-threatening blood clots. Cell nuclei are shown in blue.

A single-dose breakthrough: PfSPZ-LARC vaccines offer transformative protection against malaria

Scientists at Sanaria and Seattle Children’s Research Institute’s Center for Global Infectious Disease Research (CGIDR) have unveiled a groundbreaking malaria vaccine, Sanaria® PfSPZ-LARC2 Vaccine, designed to provide high-level protection with…

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A new study shows that postnatal exposure to tobacco smoke alters DNA methylation, which may help explain adverse health effects

How the DNA’s environment shapes smoking-related cancer risk

The study from The Hebrew University of Jerusalem, led by Prof. Sheera Adar and her graduate student Elisheva Heilbrun-Katz from The Institute for Medical Research Israel-Canada in the Faculty of…

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diabetes
Research highlights the differences between the two types of diabetes and provides new insights that could influence future treatment approaches

Could peripheral neuropathy be stopped before it starts?

An increase in high-fat, high-fructose foods in people’s diets has contributed to a dramatic increase in type 2 diabetes. This, in turn, has led to an increase in peripheral neuropathy…

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Telehealth may be closing the care gap for people with substance use disorder in rural areas

Recognition of telehealth as an effective strategy for delivering treatment for substance use disorder (SUD) has raised hopes for improving access to this treatment in settings with limited transportation or…

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Research spotlight: Projecting the impact of funding cuts to the President’s Emergency Plan for AIDS Relief (PEPFAR)

This analysis projects the impact of funding cuts to PEPFAR (the President’s Emergency Plan for AIDS Relief), a U.S. program whose investments in curbing the global HIV/AIDS epidemic have saved…

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diabetes
Research highlights the differences between the two types of diabetes and provides new insights that could influence future treatment approaches

New study finds lower cardiovascular risk in Type 1 diabetes compared to Type 2 diabetes

A new study published in JSCAI has revealed a lower risk of cardiovascular events for patients with Type 1 diabetes (often called juvenile diabetes) compared to those with Type 2 diabetes. The…

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Fischer - Mira (3)
Jared Fischer, Ph.D., and Jose Luis Montoya Mira, Ph.D., cancer researchers at Oregon Health & Science University, have developed PAC-MANN, a test that uses a small blood sample to detect changes in protease activity, a key indicator of pancreatic ductal adenocarcinoma (PDAC), the most common and deadliest form of pancreatic cancer. (OHSU/Christine Torres Hicks)

New blood test identifies hard-to-detect pancreatic cancer with 85% accuracy

A new blood test could help doctors detect pancreatic cancer earlier, potentially improving survival rates for one of the deadliest cancers. Researchers at Oregon Health & Science University have developed…

Continue ReadingNew blood test identifies hard-to-detect pancreatic cancer with 85% accuracy
diabetes
Research highlights the differences between the two types of diabetes and provides new insights that could influence future treatment approaches

Diabetes can drive the evolution of antibiotic resistance

Antibiotics are powerful, fast-acting medications designed to eradicate bacterial infections. However, in recent years, their dependability has waned as antibiotic resistant bacteria continues to evolve and spread. Staphylococcus aureus is…

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Container of peanut butter with a spoon.

Eating gradually increasing doses of store-bought peanut butter enables children with high-threshold allergy to safely consume peanuts

Children with high-threshold peanut allergy who ate gradually larger doses of store-bought peanut butter achieved significantly higher and long-lasting rates of desensitization compared to those who avoided peanuts, according to…

Continue ReadingEating gradually increasing doses of store-bought peanut butter enables children with high-threshold allergy to safely consume peanuts
peanut-butter-with-spoon
Container of peanut butter with a spoon.

Therapy helps peanut-allergic kids tolerate tablespoons of peanut butter

Eating gradually increasing doses of store-bought, home-measured peanut butter for about 18 months enabled 100% of children with peanut allergy who initially could tolerate the equivalent of at least half…

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Gita Suneja, MD, MS

Short-course radiation therapy effective for endometrial cancer patients

In a randomized clinical trial, researchers from Huntsman Cancer Institute at the University of Utah (the U) have found that short-course, higher dose vaginal brachytherapy for endometrial cancer had similar effectiveness to more frequent,…

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PPP
Tumors can drive thrombosis by releasing chemokines, secreted proteins that can circulate to the lung. This image of a lung sample shows how immune cells called macrophages release small vesicles (green) that attach to platelets (magenta), which can form life-threatening blood clots. Cell nuclei are shown in blue.

Cancer’s ripple effect may promote blood clot formation in the lungs

Blood clots form in response to signals from the lungs of cancer patients—not from other organ sites, as previously thought—according to a preclinical study by Weill Cornell Medicine, Memorial Sloan…

Continue ReadingCancer’s ripple effect may promote blood clot formation in the lungs
JamieHartmann-Boyce
Jamie Hartmann-Boyce is an assistant professor of health policy and management at the University of Massachusetts Amherst.

New study fails to show that youth vaping causes future smoking

A team of public health researchers found “very low-certainty evidence” to support a commonly held belief that nicotine vaping is a gateway to cigarette smoking for young people. “One of…

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nicotine
(Left) Nicotine withdrawal reduces nicotinic receptor activity, leading to a relative increase in muscarinic receptor activity and disrupting acetylcholine signaling balance. (Right) Suppressing striatal cholinergic interneurons or administering the muscarinic antagonist Procyclidine reduces acetylcholine release or inhibits muscarinic receptors. This action restores the balance of acetylcholine signaling by reducing the excessive muscarinic receptor activity.

Overcoming nicotine withdrawal: Clues found in neural mechanisms of the brain

According to the World Health Organization (WHO), over 22% of the global population smokes, with more than 9 million smoking-related deaths reported annually. Effective treatments to alleviate nicotine withdrawal symptoms…

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Translocation pathway and substrate binding site of SPNS1. (A) Surface representation of outward-facing cavity with lysophosphatidylcholine (LPC) is shown as sticks. (B) Interaction details of LPC with residues in the binding site.

NUS Medicine study: Inability of cells to recycle fats can spell disease

Accumulation of fat molecules is detrimental to the cell. Researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have made a breakthrough in understanding…

Continue ReadingNUS Medicine study: Inability of cells to recycle fats can spell disease
trac
Insights from an international team include identification of beneficial bacteria that thwart disease

Study of female genital tract reveals key findings

Seeking to understand what constitutes a healthy vaginal microbiome, a global research collaboration that includes a Rutgers-New Brunswick scientist has reported a series of findings, including identifying which bacteria thwart…

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Ruishan Liu, WiSE Gabilan Assistant Professor of Computer Science, USC

AI unlocks genetic clues to personalize cancer treatment

A groundbreaking study led by USC Assistant Professor of Computer Science Ruishan Liu has uncovered how specific genetic mutations influence cancer treatment outcomes—insights that could help doctors tailor treatments more effectively. The…

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Researchers from Japan, discover mitochondrial transfer from cancer cells to immune cells and metabolic reprogramming of the tumor microenvironment as a key immune evasion strategy. Targeting mitochondrial transfer can help improve the efficacy of immunotherapy in unresponsive patients.

How cancer cells trick the immune system by altering mitochondria

The immune system plays a key role in detecting and destroying cancer cells. Cancer immunotherapy works by programming immune cells to recognize and eliminate cancer cells. However, many cancers can…

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Creation of the most complete map of more than 1000 genes that influence kidney function could help experts diagnose and design targeted treatments for kidney disease

Researchers create genetic map tied to kidney disease

Over 1,000 genes may serve as possible treatment targets for individuals with kidney disease, according to a new study, published in Science, from researchers at the Perelman School of Medicine at the University of…

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Deutsch simpel
In this international study, the scientists showed that one of the adhesion G protein-coupled receptors – GPR133 – is activated by the androgenic steroid hormone 5α-DHT. Created in BioRender.

Researchers discover new mechanism for male sex hormone

Androgens are hormones that control the development of male sexual characteristics. The most powerful of the androgens is called 5α-dihydrotestosterone (5α-DHT). Among other things, it is essential for bone and…

Continue ReadingResearchers discover new mechanism for male sex hormone
smoke
A new study shows that postnatal exposure to tobacco smoke alters DNA methylation, which may help explain adverse health effects

Second-hand smoke exposure during childhood leaves its mark on children’s DNA

Children exposed to second-hand smoke at home are more likely to show certain changes in the epigenome, which can alter the way genes are expressed. These epigenetic changes could influence…

Continue ReadingSecond-hand smoke exposure during childhood leaves its mark on children’s DNA
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In a joint study, Prof. Dirk Haller and Dr. Tobias Schwerd demonstrated how the gut microbiome changes during nutritional therapy. Prof. Dr. Dirk Haller (left) is a professor of nutrition and immunology at TUM and director of the Central Institute for Nutrition and Food Research. PD Dr. Tobias Schwerd is the head of pediatric gastroenterology and hepatology at Dr. von Hauner Children's Hospital. Building on these findings, a joint clinical trial is now launching at the Dr. von Hauner Children's Hospital at LMU University Hospital Munich.

Microbiome as a potential key to better treatment: Clinical study on new therapy for Crohn’s disease

A special liquid diet, known as exclusive enteral nutrition, is an essential therapy for Crohn's disease. Patients consume only this formula for six to eight weeks, completely avoiding solid foods.…

Continue ReadingMicrobiome as a potential key to better treatment: Clinical study on new therapy for Crohn’s disease
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The biosensing platform developed by Penn State engineering researchers incorporates two-pass laser induced graphene with commercial transistors to simultaneously test for SARS-CoV-2 and vitamin C.

Biosensing platform simultaneously detects vitamin C and SARS-CoV-2

In the COVID-19 pandemic era, at-home, portable tests were crucial for knowing when to wear a mask or isolate at home. Now, Penn State engineering researchers have developed a portable…

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smoking
In 2503 children followed up from age 11 to 24 years, participation in moderate-to-vigorous physical activity either in childhood or cumulatively from childhood through young adulthood significantly decreased the incidence of tobacco smoking.

Moderate-to-vigorous exercise in childhood may significantly postpone the initiation of tobacco smoking

Teenagers may be less likely to initiate tobacco smoking if they engage in moderate-to-vigorous physical activity (MVPA) from childhood, a new study conducted in collaboration between the Universities of Bristol…

Continue ReadingModerate-to-vigorous exercise in childhood may significantly postpone the initiation of tobacco smoking
old age
Depression rates buck the trend and remain slightly higher than pre-COVID, reinforcing the need for policies addressing immediate and lingering effects of the pandemic on mental health

Mechanical heart valve replacements have better long-term survival, study finds

Patients aged between 50 to 70 years with a mechanical heart valve replacement had better long-term survival compared to those with a biological valve, new research led by the University of…

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Visualization of site-site relationship and site-risk probabilities

Disruption of a single amino acid in a cellular protein makes breast cancer cells behave like stem cells

Disruption of a single amino acid in a cellular protein makes breast cancer cells behave like stem cells   Changes to the intermediate filament (IF) protein, vimentin, were found to promote…

Continue ReadingDisruption of a single amino acid in a cellular protein makes breast cancer cells behave like stem cells
Islam and Blennow
Tohidul Islam and Kaj Blennow, Sahlgrenska Academy at the University of Gothenburg.

Opening for a new type of drug for Alzheimer’s disease

A complementary drug to combat Alzheimer’s disease could target a specific part of the nerve cell protein tau. This is the finding of research from the University of Gothenburg, which…

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cups
Warning comes after lopsided placement blocked urine flow into the bladder

Position menstrual cups carefully to avoid possible kidney problems, doctors urge

A poorly positioned menstrual cup to capture monthly blood flow may lead to more serious complications than leakage alone, warn doctors in the journal BMJ Case Reports, after treating a young…

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old age
Depression rates buck the trend and remain slightly higher than pre-COVID, reinforcing the need for policies addressing immediate and lingering effects of the pandemic on mental health

Older people in England are happier now than before the COVID pandemic, new national study suggests

Older people have greater general happiness, life satisfaction and sense of purpose than they did before the Covid-19 pandemic. That’s according to a new study which tracked 3,999 over 50s…

Continue ReadingOlder people in England are happier now than before the COVID pandemic, new national study suggests
bowel
Trial showed promising results for patients with IBD and autoimmune liver disease with 80% achieving clinical remission

Common antibiotic could treat inflammatory bowel disease, new study finds

An antibiotic used to treat infective diarrhoea could be an effective drug for a type of inflammatory bowel disease, a new study has found. Results published in the Journal of…

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Researchers used a combination of animal models, human brain tissue and molecular analysis to reveal a link between Alzheimer’s disease and issues with cell function and cholesterol in the brain

USC-led study finds potential new drug target for Alzheimer’s disease

A team of researchers from the Keck School of Medicine of USC has unlocked the details of a cellular pathway that triggers cellular inflammation and aging and is linked to…

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New Curtin University research has found exposure to outdoor air pollution and extreme temperatures during pregnancy may increase the risk of prolonged pregnancy

Born too late? Climate change may be delaying births

New Curtin University research has found exposure to outdoor air pollution and extreme temperatures during pregnancy may increase the risk of prolonged pregnancy, offering new insights into the impact of…

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T cells and natural killer cells are shown in pink, macrophages in yellow. The surrounding myeloma cells appear blue. The white structures are blood vessels. The image was acquired using spatial multi-omics methods.

When blood cancer starts to spread

When blood cancer cells break through the bone and multiply, tumor cells become dangerously diverse and the immune response in the region changes, researchers from Berlin and Heidelberg report in…

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Innovative therapies and surgical techniques can transform liver cancer care

New study offers hope to patients with advanced liver cancer, cirrhosis

The risk of developing liver cancer is increased in people who have cirrhosis, a disease in which healthy liver tissue is replaced by scar tissue. The scar tissue blocks the…

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This diagram illustrates the timeline and current status of various TB vaccine candidates in clinical trials, highlighting the diversity of vaccine types and their potential impact on TB prevention and treatment.

Breakthroughs in tuberculosis vaccine and drug development pave way for global health advancements

Despite decades of efforts, tuberculosis remains a global health crisis, claiming over 1.3 million lives annually. In a comprehensive review published in Molecular Biomedicine, an international team of researchers unveils…

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Visualization of site-site relationship and site-risk probabilities

Uncovering two rare infectious diseases which might be responsible for COVID-19

Despite extensive research, the origins of COVID-19 remain elusive. In a new study published in the KeAi journal Advances in Biomarker Sciences and Technology (ABST), an AI-driven approach was adopted…

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TB
A new study shows that tuberculosis patients cash-incentivised and counselled have a 52% lower relative risk of having an unsuccessful treatment outcome

Cash and counselling slash unsuccessful TB outcomes by half

Professor Nazir Ismail from Wits University, Johannesburg, and Dr Harry Moultrie from SA’s National Institute for Communicable Diseases (NICD) led the study, which was  published in The Lancet Infectious Diseases journal on 6 February 2025. The…

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WHO In February 2025, Uganda's Ministry of Health, WHO and partners launched a first ever vaccine trial for Ebola from the Sudan species of the virus.

Groundbreaking Ebola vaccination trial launches today in Uganda

In a global first, Uganda’s Ministry of Health, the World Health Organization (WHO) and other partners today launched a first-ever clinical efficacy trial for a vaccine from Ebola from the…

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New Dawn for Health Security and Sovereignty in Africa as Stakeholders Convene at Manufacturing Forum

The 2nd Vaccine and Other Health Products Manufacturing Forum, organized by Africa CDC, Gavi, the Vaccine Alliance, the Regionalized Vaccine Manufacturing Collaborative (RVMC), and the Unified Procurement Authority of Egypt…

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Landmark Agreement Among Africa’s Leading National Medicines Regulatory Authorities to Foster Collaboration

The Africa Centres for Disease Control and Prevention (Africa CDC) and African Union Development Agency – New Partnership for Africa’s Development (AUDA-NEPAD) are proud to announce the signing of a…

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Cardiovascular health risks continue to grow within Black communities, action needed

The American Heart Association’s 2025 Heart Disease and Stroke Statistical Update  reports that while progress has been made in reducing cardiovascular and cerebral health disparities, Black communities in the United States…

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Virtual memory T cells (TVM), activated by IL-4 during a parasitic infection in the intestine, expressing the CD22 receptor, which enables them to regulate this activation.

An unexpected mechanism regulates the immune response during parasitic infections

Researchers at the University of Liège (Belgium) have uncovered a previously unknown mechanism that regulates the immune response against parasites. During a parasitic infection, specific immune cells, known as virtual…

Continue ReadingAn unexpected mechanism regulates the immune response during parasitic infections
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Metabolic circuit map constructed from the metatranscriptome of dinoflagellate resting cyst persistence in marine sediments. (B) Schematic summary of transcriptionally active pathways revealed by metatranscriptomic analyses in this study.

Scientists enhance understanding of dinoflagellate cyst dormancy

Dinoflagellates play crucial roles in aquatic ecosystems, particularly as major contributors to harmful algal blooms. They can enter a dormant stage, known as the resting cyst stage, that allows them…

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Knockdown of CUL5 gene enhances CAR-T cells’ prolification and survival compared to conventional CAR-T cells, making them better at fighting cancer.

Gene modification could improve cancer treatment’s success rate

Researchers have identified a method to enhance the effectiveness of a promising cancer treatment. They found that modifying a specific gene improves the ability of immune cells to combat cancer…

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Recreating the Tumor Microenvironment with Bioprinting Technology for Personalized Drug Response Identification and Prediction

Decline in breast cancer screening participation rates during the COVID-19 pandemic

Tsukuba, Japan—During the coronavirus disease 2019 pandemic, breast cancer screening participation rates declined worldwide. However, in Japan, nationwide changes in the rate of breast cancer screening before and during the…

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Study shows why there are differences in prognosis between different pancreatic tumours and identifies potential avenues for improved treatment approaches

Pancreatic cancer immune map provides clues for precision treatment targeting

Pancreatic cancer patients may benefit from future precision treatments as a new study shows how some tumours may potentially be more susceptible to macrophage-based therapies.   The study which is…

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Virtual memory T cells (TVM), activated by IL-4 during a parasitic infection in the intestine, expressing the CD22 receptor, which enables them to regulate this activation.

An unexpected mechanism regulates the immune response during parasitic infections

Researchers at the University of Liège (Belgium) have uncovered a previously unknown mechanism that regulates the immune response against parasites. During a parasitic infection, specific immune cells, known as virtual…

Continue ReadingAn unexpected mechanism regulates the immune response during parasitic infections
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Study shows why there are differences in prognosis between different pancreatic tumours and identifies potential avenues for improved treatment approaches

Fear of breast cancer recurrence: Impact and coping with being in a dark place

Breast cancer is the world’s most prevalent cancer. Although earlier detection and targeted treatment have resulted in high survival rates, many breast cancer survivors experience fear of cancer recurrence. For…

Continue ReadingFear of breast cancer recurrence: Impact and coping with being in a dark place
kidney
A new study from Keck Medicine of USC finds that heavy drinkers with either diabetes, high blood pressure or a high waist circumference are as much as twice as likely to develop advanced liver disease

Why some heavy drinkers develop advanced liver disease, while others do not

Why do some people who consume a few glasses of alcohol a day develop advanced liver disease while others who drink the same amount don’t?   The answer may lie in…

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Study shows why there are differences in prognosis between different pancreatic tumours and identifies potential avenues for improved treatment approaches

Electronic reporting of symptoms by cancer patients can improve quality of life and reduce emergency visits

People with metastatic cancer who regularly report their symptoms via a home-based electronic monitoring system experienced improved quality of life, clinical outcomes and well-being, as well as fewer emergency department…

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Is CBD use during pregnancy as safe as people think? New study uncovers potential risks to babies

Cannabidiol (CBD), the component in cannabis often used for therapeutic treatments, is increasingly being used during pregnancy as a means of managing symptoms such as nausea, anxiety and sleep. Though…

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Only seven out of 100 people worldwide receive effective treatment for their mental health or substance use disorders

New research estimates that globally, only 6.9 per cent of people with mental health or substance-use disorders receive effective treatment for their disorders.   Researchers from the University of British…

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Representative immunofluorescence images showing normal oral epithelial cells (left) and early stages of oral cancer (right

How healthy stem cells turn into oral cancer

Nearly 60,000 people are diagnosed with oral cancer in the U.S. every year, according to the American Cancer Society, and the rate of new cases continues to rise. Now, researchers…

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Study shows why there are differences in prognosis between different pancreatic tumours and identifies potential avenues for improved treatment approaches

Outside-In Signaling Shows a Route Into Cancer Cells

A new study shows how an anticancer drug triggers an “outside in” signal that gets it sucked into a cancer cell. The work, published Jan. 29 in Nature Communications, reveals a…

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Later-onset menopause linked to healthier blood vessels, lower heart disease risk

Later-onset menopause linked to healthier blood vessels, lower heart disease risk

Women who go through menopause later in life have healthier blood vessels for years to come than those who go through it earlier, according to new University of Colorado Boulder…

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Juicing may harm your health in just three days, new study finds

Juicing may harm your health in just three days, new study finds

CHICAGO --- Think your juice cleanse is making you healthier? A new Northwestern University study suggests it might be doing the opposite. The study, recently published in Nutrients, found that a…

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WHO/L. Mackenzie A member of the ring vaccination team vaccinates a man in Bosolo village. Photo/WHO

WHO and partners enable access to candidate vaccine and treatments for outbreak of Sudan Ebola virus disease in Uganda

WHO and partners have immediately boosted their support to the Ugandan government’s response to an outbreak of Sudan virus disease outbreak (SVD, part of the Ebola family), including by facilitating…

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The Growing Threat of Antibiotic-Resistant Bacteria and Potential Solutions

Antibiotic-resistant bacteria pose a significant and growing global health threat. As bacteria evolve to resist the effects of antibiotics, once-treatable infections become harder, and sometimes impossible, to cure. According to…

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